7
1
12
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T62104 |
NS2B/NS3-IN-5
|
||
NS2B/NS3-IN-5 (Compound 25b) 是一种变构的 DENV2 和 ZIKV NS2B/NS3 蛋白酶抑制剂,对 ZIKV 和 DENV2 的 NS2B/NS3 蛋白酶的IC50值分别为 0.67 μM 和 4.38 μM。 | |||
T74403 | NS5A-IN-1 | ||
NS5A-IN-1 是一种丙型肝炎病毒NS5A 抑制剂 Pibrentasvir(ABT-530)的前体。 | |||
T73223 | NS5A-IN-3 | HCV Protease | Microbiology/Virology; Proteases/Proteasome |
NS5A-IN-3 (Compound 15) 为高效NS5A抑制剂,对HCV基因型1b显示出高效力,并对基因型3a (GT 3a) 活性提升以及展现出良好的代谢稳定性。NS5A-IN-3相较于daclatasvir,对基因型1b具有更高的耐药门槛。 | |||
T74495 | NS5A-IN-4 | ||
NS5A-IN-4 (Compound 1.12) 是一种具有口服活性的泛基因型丙型肝炎病毒 (HCV)NS5A 抑制剂,对gT1b、gT1a、gT2a、gT3a,gT4a 和gT5a 的IC50分别为 1.2、2296、4.6、362、10.3 和 693 pM。 | |||
T73834 | NS5A-IN-2 | HCV Protease | Microbiology/Virology; Proteases/Proteasome |
NS5A-IN-2 (Compound 33)为一种高效的NS5A抑制剂,对HCV基因型1b展现出极高效力,并对基因型3a (GT 3a) 亦具备增强活性与良好的代谢稳定性。 | |||
T6481 |
Droxinostat
NS 41080,4-(4-氯-2-甲基苯氧基)-N-羟基丁酰胺 |
Apoptosis; HDAC | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Droxinostat (NS 41080) 是HDAC3、HDAC6和HDAC8抑制剂,IC50分别为16.9、2.47和1.46 μM。 | |||
T36336 | Burnettramic Acid A | ||
Burnettramic acid A is a fungal metabolite originally isolated fromA. burnettiithat has diverse biological activities.1It is active againstB. subtilis,S. aureus,C. albicans, andS. cerevisiae(IC50s = 2.3, 5.9, 0.5, and 0.2 μg/ml, respectively). Burnettramic acid A is cytotoxic to NS-1 murine myeloma cells but not neonatal foreskin fibroblasts (IC50s = 13.8 and >100 μg/ml, respectively). 1.Li, H., Gilchrist, C.L.M., Lacey, H.J., et al.Discovery and heterologous biosynthesis of the burnettramic aci... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T36337 |
Burnettramic Acid A aglycone
|
||
Burnettramic acid A aglycone is a fungal metabolite and an aglycone form of burnettramic acid A originally isolated fromA. burnettiithat has anticancer activity.1It is cytotoxic to NS-1 murine myeloma cells but not neonatal foreskin fibroblasts (IC50s = 8.4 and >100 μg/ml, respectively). 1.Li, H., Gilchrist, C.L.M., Lacey, H.J., et al.Discovery and heterologous biosynthesis of the burnettramic acids: Rare PKS-NRPS-derived bolaamphiphilic pyrrolizidinediones from an Australian fungus, Aspergillus... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05095 |
RAF1 Protein, Human, Recombinant (His & GST)
Raf-1 proto-oncogene, serine/threonine kinase,CRAF,NS |
Human | Baculovirus Insect Cells |
RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell p... | |||
TMPY-05024 |
Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-NS5 protein (His)
|
ZIKV | Baculovirus Insect Cells |
Zika virus NS5 is involved in methytransferase and RNA guanylytransferase activities and capping and synthesis of RNA. And, NS5 is also an RNA-dependent RNA polymerase. | |||
TMPY-00279 |
Dengue virus DENV-2 (strain New Guinea C) NS5 (methyltransferase domain)/Nonstructural protein 5 Protein (His)
chemokine (C-X-C motif) ligand 8 |
DENV | E. coli |
Dengue virus DENV-2 (strain New Guinea C) NS5 (methyltransferase domain)/Nonstructural protein 5 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 35.5 kDa and the accession number is AAC59275.1. | |||
TMPH-03467 |
CspA Protein, Salmonella enteritidis, Recombinant (His & Myc)
CS7.4,CSP-A,cspA,Cold shock protein CspA,7.4 kDa cold shock ... |
Salmonella enteritidis | E. coli |
Binds to and stimulates the transcription of the CCAAT-containing, cold-shock-inducible promoters of the H-NS and GyrA proteins. Binds also to the inverted repeat 5'-ATTGG-3'. CspA Protein, Salmonella enteritidis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.7 kDa and the accession number is P0A9Y5. | |||
TMPY-05308 |
CD45 Protein, Human, Recombinant (aa 1-529, His)
GP180,B220,L-CA,protein tyrosine phosphatase, receptor type,... |
Human | HEK293 Cells |
CD45 Protein, Human, Recombinant (aa 1-529, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.4 kDa and the accession number is P08575-5. | |||
TMPY-05387 |
SLAMF7 Protein, Human, Recombinant (hFc)
SLAM family member 7,19A,SLAM7,CS1,CD319,CRACC |
Human | HEK293 Cells |
SLAMF7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5. | |||
TMPY-04318 |
GRIK2 Protein, Human, Recombinant (hFc)
GLUR6,EAA4,MRT6,GLR6,glutamate receptor, ionotropic, kainate... |
Human | HEK293 Cells |
GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD). The gene coding for GRIK2 has been suggested as a candidate gene for autism based on its localization in the autism-specific region on chromosome 6q21 and the involvement of receptor protein in cognitive functions like learning and memory. GRIK2 belongs to the gl... | |||
TMPY-05547 |
SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated
CS1,SLAM7,CD319,SLAM family member 7,CRACC,19A |
Human | HEK293 Cells |
SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5. | |||
TMPY-05498 |
SR-BI/SCARB1 Protein, Human, Recombinant (hFc)
HDLQTL6,SR-BI,SRB1,CD36L1,CLA-1,CLA1,scavenger receptor clas... |
Human | HEK293 Cells |
SR-BI/SCARB1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.4 kDa and the accession number is Q8WTV0-5. | |||
TMPJ-00854 |
ETS1 Protein, Human, Recombinant (His)
V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 (Avian),... |
Human | E. coli |
ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or repressors of numerous genes. They are involved in stem cell development, cell senescence and death, and tumorigenesis. ETS1 is a transcription factor, containing one ETS DNA-binding domain and one PNT (pointed) domain. it has been shown to interact with TTRAP, UBE2I and Death As... | |||
TMPK-01357 |
SIRP alpha V5 Protein, Human, Recombinant (His & Avi)
MFR,PTPNS1,P84,BIT,MYD-1,MYD1,SHPS-1,SIRPA,SIRP α,S... |
Human | HEK293 Cells |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal. | |||
TMPK-01363 |
SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated
SIRP alpha,MFR,PTPNS1,SIRP α V5,P84,SHPS-1... |
Human | HEK293 Cells |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c... |